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Mamamoth DNA 'Cut up'; Mouse eggs within. But The Clones of Clone is the Piping Dream.



A handful of 28million year old cell cells were spent in recent experiments in a new experiment, but there is a long way of cloning the ice cattle.

experiment, the researchers removed cells from Yuka, mummy oily mammals ( Mammuthus primigenius ) whose remains were found in the Siberian carbon in 2011. Then, scientists discovered the smallest nuclei damage (structures containing genetic material

Initially, this maneuver caused "activation" of the mammos chromosomes, as some biological reactions occurred before the cell is divided within the mouse cell. These reactions to stop it early, probably, partly, because the massive DNA was severely damaged after 28,000 years of undergrounding into fuel, the researchers said. [In Photos: Mummified Woolly Mammoth Discovered]

But what Why did the researchers put huge DNA into mouse eggs? The answer relates to the ability of a egg to replicate DNA and divide it into more cells.

"The whole cellular machinery is alive by the eggs that you might need to correct error and fix damage that occurred within the nucleus, "said Beth Shapiro, professor of ecology and evolutionary biology at the University of California, Santa Cruz, who was not involved in the study. "[The scientists] basically just [the mammoth nuclei] into it and said, 'All right, cellular machinery, do your thing."

And, first, the cellular machinery tried to fix damaged DNA within the chromosomes and assembled the piece of broken pieces, Shapiro said. "But [the egg] just can't do so much," she told Live Science. "When the nuclei are severely damaged, then this cannot be reconstructed as to what you would have to do to bring it back to life."

As a result, none of the hybrid cells became mouse mammals into the cell division, a step necessary to create embryo and, possibly, one day, destroy a clone.

"The results presented here show us again the de facto impossible of health by the NT technology [nuclear-transfer] cloning," the researchers wrote in the study, published online March 1

1 in the journal Scientific Reports .

In another way, "it is a clear indication that this approach will not work to much cloning," said Shapiro. "The cells are too damaged."

As soon as the dog died, his DNA began to degrade. This is how bacteria from the stomach of the mammals and surrounding environment began to affect the cells of dead mammals. Ultraviolet (UV) radiation from the sun broke down more of the genetic material, and these processes continued for eons. As a result, DNA fragments in the nucleus survived to the present day can only ten of the surviving coins, rather than the millions found in the DNA of modern elephants, said Shapiro.

However, the study is still exciting, said Rebekah Rogers, an assistant bioinformatics professor at the University of North Carolina at Charlotte, who was not involved in the research. For example, if researchers can insert small fragments of DNA DNA into a cell line, what could be said is what makes that DNA in a living creature, she said. [Mammoth Resurrection: 11 Hurdles to Bringing Back an Ice Age Beast]

In the study, the researchers said that "our approach solves the way to assess the biological activities of a nucleus in extinct animal species."

However, Rogers said that she would like to see more evidence that the mother of chromosomes made it into a mouse egg. "You may have a modified mouse chromosome or some other DNA pollution," she said. "This unusual demand has put them into a huge chromosome into a mouse [egg]. I would like to see enough evidence for that kind of demand."

Other research groups are trying to rebuild the mama, using different technology. George Church, a geneticist at Harvard University and Massachusetts Institute of Technology in charge of the Harvard Islands Mammy Revival team, is taking one approach. It is using CRISPR – a tool that can edit DNA bases or letters – to insert wool mammal genes into the DNA of Asian elephants, which are closely associated with the deceased animals.

"They don't want a huge genome to revive," Shapiro said. "They want to create one by cutting an elephant genome. That way, they could have a living cell as a final product."

Controversy has been used to restore the mammals of the age. Many guardians argue that resources should be spent on animals currently threatened or endangered rather than beasts that have since died.

Originally published on Live Science .


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