Alexander Wild Courtesy / University of Wisconsin
Anyone likes a cockroach in his house. But before you unsuccessfully succeed the adjudicator, consider this: that a six-foot critter could save one day your life.
That's right. Insects that may spread diseases may help them cure them. Or instead, the microbes that were living inside them could. Scientists found many of the micro-organisms living in insects or insects that offer antimicrobial compounds, and some may develop new antibiotic drugs.
They can not come too fast. Acute antibiotics are more resistant to infections, and the new antibiotic drug pipeline has slowed down to trickle.
"There is a growing demand [for antibiotics] and a reduced supply," explains Gerry Wright, led by Michael G Institute of Infectious Disease Research DeGroote Institute at McMaster University.
Most of the antibiotic drugs found out of the bacteria that live in the soil. But Cameron Currie, a bacteriological professor at the University of Wisconsin-Madison, says the soil is searching for new antibiotics.
"They keep having already known antibiotics," says Currie. "There is a common sense of good antibiotics from the soil … dry."
Unfortunately, there may be another good. Recently, Currie published a team of 28 paper researchers in Natural Communications which shows that many of the bacteria that live in insects live the germs caused by sick people.
"The planet has 10 million species [of insect]," says Currie. "This implies a huge impression on many of the new compounds [antibiotic]"
There is a complete ecosystem of micro-organisms on each insect, similar to the microbiology received by humans. And there is one standard that many of the insect-related microbes are in general, said Jonathan Klassen, a professor of molecular and cellular biological in the University of Connecticut, says the study.
Not another one gets good.
And it does not come together, it means they are constantly trying to kill each other through biochemical warfare. Many of the microorganisms in insects make compounds that are toxic to other microbes – in essence, natural antibiotics.
Currie's attention to some of the natural antibiotics attracted him and was a student, researching foliage of leaf cuttings.
Book cut illustrations are among Best Gardeners. They do not really eat the leaves they cut – instead they use them to nourish a special type of fungus for food. However, it is not easy to become a fungus farmer.
"Like human agriculture, diseases of the disease have problems," says Currie. "I found a specialized pathogen that makes attacks on their fungus garden."
Fortunately, the places have tools to deal with the problem. There are species of bacteria that are living on the ultrasound that produces toxin that kills the pathogen. Like the pesticides used by gardener use, the toxin keeps the animals that are free of a garden disease.
Currie's curiosity discovery suggested. If ants could not use these bacterial compounds to treat disease in their fungus gardens, doctors can use them to treat disease in humans? If so, what are other insects that could have microbes fight with diseases?
To answer those questions, Currie and his team spent years to collect thousands of insects, including cockroaches, from Alaska to Brazil.
"Every couple of months someone goes out somewhere to collect something," Klassen, who was currently working as a postdoctoral researcher, remembers the project.
The team tested bacteria from each insect to determine whether they could kill common human pathogens, such as E. coli and a resistant of methyl Staphylococcus aureus (MRSA). Then they compared the results from defining insect bacteria on definitions drawn from plants and soils.
"I was surprised that [insect strains] was not good, but it seems that [pathogens] would be blocked," says Currie. 19659008] New antibiotics test
When a scientist found that a bacterial pressure can kill germs, the next step in drug development is to determine what bacterial compound is responsible for antimicrobial activity – like cooking by searching the secret ingredient into a very sensitive soup.
Currie's staff found a little bit of bacterial types betting in insects. And everyone could have a secret ingredient with a new antibiotic compound.
It was great achievements. But researchers went a step further. They only requested one compound of bacteric pressure betting and showed that it could prevent fungal infections in mice, an important step in drug development.
The combination of cyphomycin is found on Brazilian fungus farming frauds, closing close relatives of Currie ants as a PhD student. Although it is far from being approved drugs, the research indicates that new compounds can be communicated to science from animals.
Wright, an antibiotic researcher who did not participate in the study, says that previous research has shown that individual insect species have antimicrobial compounds. But this is the first study to be comprehended comprehensively as insective as a group of new antimicrobials.
"No one has done anything on this scale before," explains Wright.
Currie hopes that cyphomycin may be one day to treat yeast infections in humans. But before this happens, it must take a year of further testing.
"It's [cyphomycin] million miles away [from approval]," says Wright. "That is a reality of drug discovery."
Still, Wright says that the researchers have tackled one of the most difficult difficulties in drug development by showing that the compound works in mice.
In the case of Klassen, the bets are too high to try.
"The efforts such as this study are crucial to keeping the antibiotic pipeline flowing so that the disease can not get the manual," he says.
In the end, the world's consequences are not enough antibiotics for scientists to look for scientists on new drugs in uncommon places – even if this means looking at a cockroach.
Paul Chisholm is an independent writer in Rapid City, SD. You can find it on Twitter: @PaulJChisholm .